Southeast Missouri State University is fully accredited by
- North Central Association Of Colleges and Schools
- National Council for the Accreditation of Teacher Education
The University holds specific program accreditations from
- American Assembly of Collegiate Schools of Business
- American Chemical Society
- American Speech-Language-Hearing Association
- Association of Technology Management and Applied Engineering
- Council on Social Work Education
- National Association of Schools of Music
- Commission on Collegiate Nursing Education (CCNE)
- National Recreation and Park Association
- Council for Accreditation of Counseling and Related Educational Programs (CACREP)
- Interstate School Leaders Licensure Consortium (ISLLC)