From Cape Girardeau
- Take I-55 south to Sikeston - approximately 28 miles.
- Turn west onto Exit 66B / US 60 West toward Poplar Bluff - approximately 50 miles.
- From US 60 West, take the second Poplar Bluff exit onto US 67 South/Westwood Boulevard.
- Go 1.6 miles and turn right (west) onto Three Rivers Boulevard.
- Go 0.7 miles on Three Rivers Boulevard to the TRCC campus.
- Take HWY 53 to Poplar Bluff.
- Turn right onto HWY 67 North/Westwood Boulevard and go approximately 1.7 miles.
- Turn left onto PP HWY/Kanell Boulevard and go approximately 0.7 miles.
- Turn right onto Hershell Bess Boulevard and go 0.6 miles to the TRCC campus.