Southeast Missouri State University - Sikeston (SES) is located at 2401 North Main or on Highway 61 North in Sikeston, Mo.

Traveling North on Interstate 55

• Take exit 69
• Turn left (West) on state road HH.  
• Travel West on HH for approximately four miles.
• Come to stop light at Highway 61 North—turn right
• SES will be on the left

Traveling South on Interstate 55

• Take exit 69
• Turn right (West) on state road HH.  
• Travel West on HH for approximately four miles.
• Come to stop light at Highway 61 North—turn right
• SES will be on the left