Southeast Missouri State University - Sikeston (SES) is located at 2401 North Main or on Highway 61 North in Sikeston, Mo.

Traveling North on Interstate 55 - take exit 69
Turn left (West) on state road HH.  
Travel West on HH for approximately four miles.
Come to stop light at Highway 61 North—turn right
SES will be on the left

Traveling South on Interstate 55 - take exit 69
Turn right (West) on state road HH.  
Travel West on HH for approximately four miles.
Come to stop light at Highway 61 North—turn right
SES will be on the left

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